(details from "Minerve chassant les Vices du Jardin de la Vertu (Minerva expelling the Vices from the Garden of Virtues)"), 1506 Andrea Mantegna Louvre Museum, Paris, France

Male Devil with unilateral gynecomastia or unilateral amastia (both quite rare anomalies among humans). This Devil carries many sacks with seeds of diverse "evil" including sacks labeled mala for evil, peiora for worse, pesima also for worse, immortale odium for eternal hate, and malitiae or malice. Also note a simian or single transverse palmar flexion crease characteristic of simians (simian flexion crease) often found among persons with Down Syndrome.