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"Neurofibromatosis type 1 or NF-1 " (see details) (see related A), 1622 Jusepe de Ribera (known as Jose de Ribera) (1591-1652) Gemaldgallerie, Berlin, Germany

My impression is that this illustration portrayes a large pedunculated "bag-like or "sac-like" tumor, probably a plexiform neurofibroma. Also shown are multiple small fleshy facial tumors presumably also neurofibromas. 
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