"Ferdinando I d'Asburgo Imperatore (1527-1564)" (see related A | B | C | D | E), 1532 Cristofano dell'Altissimo (c. 1525-1605) Uffizi Gallery, Florence, Tuscany, Italy

Younger brother of Charles V - their parents were Juana or Joanne of Castille and Felipe el Hermoso ... both inherited an autosomal dominant mutation not evident in portraits of their mother nor father ... so? were both of them "bastards", illegitimate - unlikely but possible in view that their mother was declared "loca" or "mad", so if she had something to say nobody would listen ... the mutation causes an overgrown mandible or jaw and concurrently a large nose, as evident among many members of the Habsburg (Hapsburg) family. 

Please see other comments in related images.

20210413 ww